Myogenin

Myogenin (myogenic factor 4)
Identifiers
Symbols	MYOG ; MYF4; bHLHc3; myf-4
External IDs	OMIM: 159980 MGI: 97276 HomoloGene: 1854 GeneCards: MYOG Gene
Gene ontology Molecular function • RNA polymerase II regulatory region sequence-specific DNA binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • core promoter binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding • transcription factor activity, sequence-specific DNA binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • protein binding • chromatin DNA binding • sequence-specific DNA binding • protein heterodimerization activity • E-box binding Cellular component • nucleus • nucleoplasm • transcription factor complex • protein-DNA complex Biological process • ossification • cell cycle • skeletal muscle tissue development • negative regulation of cell proliferation • response to gravity • positive regulation of myotube differentiation • skeletal muscle atrophy • positive regulation of muscle atrophy • regulation of satellite cell proliferation • response to muscle activity involved in regulation of muscle adaptation • response to electrical stimulus involved in regulation of muscle adaptation • striated muscle atrophy • response to denervation involved in regulation of muscle adaptation • skeletal muscle cell differentiation • muscle cell differentiation • muscle cell fate commitment • mRNA transcription from RNA polymerase II promoter • skeletal muscle tissue regeneration • myoblast differentiation • positive regulation of myoblast differentiation • negative regulation of glycolytic process • positive regulation of transcription from RNA polymerase II promoter • skeletal muscle fiber development • positive regulation of skeletal muscle fiber development • positive regulation of muscle cell differentiation • positive regulation of cell cycle arrest • cellular response to magnetism • cellular response to lithium ion • cellular response to retinoic acid • cellular response to growth factor stimulus • cellular response to estradiol stimulus • regulation of myoblast fusion • positive regulation of myoblast fusion • positive regulation of oxidative phosphorylation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4656	17928
Ensembl	ENSG00000122180	ENSMUSG00000026459
UniProt	P15173	P12979
RefSeq (mRNA)	NM_002479	NM_031189
RefSeq (protein)	NP_002470	NP_112466
Location (UCSC)	Chr 1: 203.08 – 203.09 Mb	Chr 1: 134.29 – 134.29 Mb
PubMed search	[1]	[2]

Myogenin (myogenic factor 4), also known as MYOG, is a gene.

Myogenin is a muscle-specific basic-helix-loop-helix (bHLH) transcription factor involved in the coordination of skeletal muscle development or myogenesis and repair. Myogenin is a member of the MyoD family of transcription factors, which also includes MyoD, Myf5, and Mrf4.

In mice, myogenin is essential for the development of functional skeletal muscle. Myogenin is required for the fusion of myogenic precursor cells to either new or previously existing fibers during the process of differentiation in myogenesis. When the DNA coding for myogenin was knocked out of the mouse genome, severe skeletal muscle defects were observed. Mice lacking both copies of myogenin (homozygous-null) suffer from perinatal lethality due to the lack of mature secondary skeletal muscle fibers throughout the body.

In cell culture, myogenin can induce myogenesis in a variety of non-muscle cell types.

Interactions

Myogenin has been shown to interact with:

• MDFI,
• POLR2C,
• Serum response factor
• Sp1 transcription factor, and
• TCF3.

External links

• Myogenin at the US National Library of Medicine Medical Subject Headings (MeSH)