MKX

This article is about the protein. For the Mortal Kombat video game, see Mortal Kombat X. For other uses, see MKX (disambiguation).

Mohawk homeobox
Identifiers
Symbols	MKX ; C10orf48; IFRX; IRXL1
External IDs	OMIM: 601332 MGI: 2687286 HomoloGene: 72239 GeneCards: MKX Gene
Gene ontology Molecular function • RNA polymerase II transcription factor activity, sequence-specific DNA binding • RNA polymerase II transcription factor binding • sequence-specific DNA binding Cellular component • nucleus Biological process • negative regulation of transcription from RNA polymerase II promoter • tendon sheath development • transcription from RNA polymerase II promoter • muscle organ development • positive regulation of gene expression • collagen fibril organization • positive regulation of collagen biosynthetic process • tendon cell differentiation • negative regulation of myoblast differentiation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	283078	210719
Ensembl	ENSG00000150051	ENSMUSG00000061013
UniProt	Q8IYA7	Q8BIA3
RefSeq (mRNA)	NM_001242702	NM_177595
RefSeq (protein)	NP_001229631	NP_808263
Location (UCSC)	Chr 10: 27.67 – 27.75 Mb	Chr 18: 6.91 – 7 Mb
PubMed search	[1]	[2]

Homeobox protein Mohawk, also known as iroquois homeobox protein-like 1, is a protein that in humans is encoded by the MKX (mohawk homeobox) gene.

Function

MKX is a member of an Iroquois (IRX) family-related class of 'three-amino acid loop extension' (TALE) atypical homeobox proteins characterized by 3 additional amino acids in the loop region between helix I and helix II of the homeodomain.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.