Apoptosis-antagonizing transcription factor
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Protein AATF is a protein that in humans is encoded by the AATF gene.[1][2][3]
Function
The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis.[3]
Interactions
Apoptosis-antagonizing transcription factor has been shown to interact with:
References
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External links
- AATF protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
- AATF human gene location in the UCSC Genome Browser.
- AATF human gene details in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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