HSF1

Heat shock factor protein 1 is a protein that in humans is encoded by the HSF1 gene.

Function

The product of this gene is a heat-shock transcription factor. Transcription of heat-shock genes is rapidly induced after temperature stress. Hsp90, by itself and/or associated with multichaperone complexes, is a major repressor of this gene.

Mechanism of action

HSF1 exists as an inactive monomer in a complex with Hsp40/Hsp70 and Hsp90. Upon stress, such as elevated temperature, HSF1 is released from the chaperone complex and trimerizes. HSF1 is then transported into the nucleus where it is hyperphosphorylated and binds to DNA containing heat shock elements (NGAAN). HSF1's target genes include major inducible heat shock proteins such as Hsp72, and noncoding RNA within Satellite III repeat regions. Its attenuation phase is initiated as a negative feedback loop with its gene product Hsp70 binding to its transactivation domain.

Relevance

HSF1 is a promising drug target in cancer and proteopathy.

Interactions

HSF1 has been shown to interact with:

• CEBPB,
• HSF2,
• HSPA1A,
• HSPA4,
• Heat shock protein 90kDa alpha (cytosolic), member A1
• NCOA6,
• RALBP1, and
• SYMPK.

See also

• Heat shock factor

External links

• HES1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
• FactorBook HSF1

This article incorporates text from the United States National Library of Medicine, which is in the public domain.