TRIM33
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Tripartite motif-containing 33 (TRIM33) also known as transcriptional intermediary factor 1 gamma (TIF1-γ), is a human gene.[1][2]
The protein encoded by this gene is thought to be a transcriptional corepressor. However unlike the related TIF1-α and TIF1-β proteins, few transcription factors such as Smad4 that interact with TIF1-γ have been identified.[1]
Contents
Structure
The protein is a member of the tripartite motif family.[3] This motif includes three zinc-binding domains:
- RING
- B-box type 1 zinc finger
- B-box type 2 zinc finger
and a coiled-coil region.
Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined.[1]
Interactions
TRIM33 has been shown to interact with TRIM24.[4]
Role in cancer
TRIM33 acts as a tumor suppressor gene preventing the development chronic myelomonocytic leukemia.[5] TRIM33 regulates also the TGF-β1 receptor and promotes physiological aging of hematopoietic stem cells. [6] TRIM33 acts as an oncogene by preventing apoptosis in B-cell leukemias.[7]
References
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External links
- TRIM33 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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