Nuclear receptor coactivator 3
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). The nuclear receptor coactivator 3 also known as NCOA3 is a protein that, in humans, is encoded by the NCOA3 gene.[1][2] NCOA3 is also frequently called 'amplified in breast 1' (AIB1), steroid receptor coactivator-3 (SRC-3), or thyroid hormone receptor activator molecule 1 (TRAM-1).
Contents
Function
NCOA3 is a transcriptional coactivator protein that contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity. NCOA3 is recruited to DNA promotion sites by ligand-activated nuclear receptors. NCOA3, in turn, acylates histones, which makes downstream DNA more accessible to transcription. Hence, NCOA3 assists nuclear receptors in the upregulation of gene expression.[3][4]
Clinical significance
The ratio of PAX2 to AIB-1 protein expression may be predictive of the effectiveness of tamoxifen in breast cancer treatment.[5][6]
Interactions
Nuclear receptor coactivator 3 has been shown to interact with:
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- Androgen receptor,[7][8][9]
- CHUK[10] and
- CREB-binding protein,[10][11]
- DDX17,[12]
- DDX5,[12]
- Estrogen receptor alpha,[12][13][14]
- Estrogen receptor beta,[13][15]
- Glucocorticoid receptor,[16][17]
- IKBKG,[10]
- IKK2,[10]
- Peroxisome proliferator-activated receptor gamma,[18] and
- Retinoid X receptor alpha.[19][20]
References
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External links
- nuclear receptor coactivator 3 at the US National Library of Medicine Medical Subject Headings (MeSH)
- NURSA C91
Further reading
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