CARM1

coactivator-associated arginine methyltransferase 1
File:PDB1.png Crystal Structure of Coactivator Associated Arginine Methyltransferase 1
Identifiers
Symbol	CARM1
Entrez	10498
HUGO	23393
OMIM	603934
RefSeq	XM_032719
UniProt	Q86X55
Other data
EC number	2.1.1.125
Locus	Chr. 19 p13.2

coactivator associated arginine methyltransferase 1-like
Identifiers
Symbol	CARM1L
Entrez	256280
HUGO	23392
RefSeq	XM_171224
UniProt	Q5SZY8
Other data
Locus	Chr. 9 p24.2

CARM1 (coactivator-associated arginine methyltransferase 1), also known as PRMT4 (protein arginine N-methyltransferase 4), is an enzyme (EC 2.1.1.125) encoded by the CARM1 gene found in human beings, as well as many other mammals. It has a polypeptide (L) chain type that is 348 residues long, and is made up of alpha helices and beta sheets. Its main function includes catalyzing the transfer of a methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins to form methylated arginine derivatives and S-adenosyl-L-homocysteine. CARM1 is a secondary coactivator through its association with p160 family (SRC-1, GRIP1, AIB) of coactivators. It is responsible for moving cells toward the inner cell mass in developing blastocysts. This gene also plays an important role in androgen receptors and may play a role in prostate cancer progression.

See also

• histone-arginine N-methyltransferase

External links

• coactivator-associated arginine methyltransferase 1 at the US National Library of Medicine Medical Subject Headings (MeSH)
• NURSA C30