Roxatidine acetate

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Roxatidine acetate
Roxatidine acetate.svg
Systematic (IUPAC) name
2-oxo-2-(3-[3-(piperidin-1-ylmethyl)phenoxy]propylamino)ethyl acetate
Clinical data
Routes of
administration		 Oral
Pharmacokinetic data
Bioavailability 80–90%
Protein binding 5–7%
Metabolism Hepatic deacetylation
Minor involvement of CYP2D6 and CYP2A6
Biological half-life 5–7 hours
Excretion Renal
Identifiers
CAS Number 78628-28-1 N
ATC code A02BA06 (WHO)
PubChem CID: 5105
DrugBank DB08806 YesY
ChemSpider 4926 YesY
UNII IV9VHT3YUM YesY
KEGG D08495 YesY
ChEMBL CHEMBL46102 YesY
Chemical data
Formula C19H28N2O4
Molecular mass 348.437 g/mol
  • O=C(OCC(=O)NCCCOc1cc(ccc1)CN2CCCCC2)C
  • InChI=1S/C19H28N2O4/c1-16(22)25-15-19(23)20-9-6-12-24-18-8-5-7-17(13-18)14-21-10-3-2-4-11-21/h5,7-8,13H,2-4,6,9-12,14-15H2,1H3,(H,20,23) YesY
  • Key:SMTZFNFIKUPEJC-UHFFFAOYSA-N YesY
 NYesY (what is this?)  (verify)

Roxatidine acetate is a specific and competitive histamine H2 receptor antagonist drug that is used to treat gastric ulcers, Zollinger–Ellison syndrome, erosive esophagitis, gastro-oesophageal reflux disease, and gastritis.[1][2]

Pharmacodynamic studies showed that 150 mg of roxatidine acetate were optimal in suppressing gastric acid secretion, and that a single bedtime dose of 150 mg was more effective than a dose of 75 mg twice daily in terms of inhibiting nocturnal acid secretion.[1]

It is available in countries including China, Japan, Korea, Germany, Italy, the Netherlands, Greece and South Africa.[2]

References

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  1. ↑ 1.0 1.1 Lua error in package.lua at line 80: module 'strict' not found.
  2. ↑ 2.0 2.1 BioSpectrum Bureau 1 November 2012 Sinhuan's generic heart drug gets production approval
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