Lupitidine
From Infogalactic: the planetary knowledge core
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| Systematic (IUPAC) name | |
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2-[2-[[5-(2-aminopropan-2-yl)furan-2-yl]methylsulfanyl]ethylamino]-5-[(6-methylpyridin-3-yl)methyl]-1H-pyrimidin-6-one
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| Identifiers | |
| CAS Number | 83903-06-4 |
| ATC code | None |
| PubChem | CID: 51670 |
| ChemSpider | 3577726 |
| UNII | WF028DWK9N  |
| KEGG | D04794 |
| Chemical data | |
| Formula | C21H27N5O2S |
| Molecular mass | 413.54 g/mol |
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Lupitidine (code name SK&F 93479) is a long-acting H2 receptor antagonist[1] described as an antiulcer agent. It was shown to inhibit nocturnal gastric acid secretion[2] and, in experiments on rodents, produced diffuse neuroendocrine cell hyperplasia and an increase in multifocal glandular hyperplasia due to hypergastrinemia resulting from the pharmacological suppression of gastric acid secretion.[3]
Synthesis[4]
References
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- ↑ Lam, B. L.; Pridgen, L. N.; 1982, U.S. Patent 4,352,933
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- H2 receptor antagonists
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