Sonidegib

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Systematic (IUPAC) name
N-[6-[(2S,6R)-2,6-Dimethylmorpholin-4-yl]pyridin-3-yl]-2-methyl-3-[4-(trifluoromethoxy)phenyl]benzamide
Clinical data
Trade names Odomzo[1]
AHFS/Drugs.com entry
Legal status
Routes of
administration		 Oral
Identifiers
ATC code L01XX48 (WHO)
PubChem CID: 24775005
ChemSpider 25027390
ChEBI CHEBI:90863 YesY
Chemical data
Formula C26H26F3N3O3
Molecular mass 485.498 g/mol
  • C[C@@H]1CN(C[C@@H](O1)C)C2=NC=C(C=C2)NC(=O)C3=CC=CC(=C3C)C4=CC=C(C=C4)OC(F)(F)F
  • InChI=1S/C26H26F3N3O3/c1-16-14-32(15-17(2)34-16)24-12-9-20(13-30-24)31-25(33)23-6-4-5-22(18(23)3)19-7-10-21(11-8-19)35-26(27,28)29/h4-13,16-17H,14-15H2,1-3H3,(H,31,33)/t16-,17+
  • Key:VZZJRYRQSPEMTK-CALCHBBNSA-N

Sonidegib (INN), also known as LDE225 and marketed as Odomzo,[2] is a Hedgehog signaling pathway inhibitor (via smoothened antagonism) being developed as an anticancer agent by Novartis.[3][4]

Approvals and indications

It was approved by the FDA for treating basal cell carcinoma in July 2015[5][2] and is awaiting approval in the EU. In the EU, the agent has received positive opinion from the CHMP for approval.

Investigations

It has been investigated as a potential treatment for:

It has demonstrated significant efficacy against melanoma in vitro and in vivo.[24] It also demonstrated efficacy in a mouse model of pancreatic cancer.[25]

Reference list

  1. ↑ FDA Approves Odomzo (sonidegib) for Locally Advanced Basal Cell Carcinoma
  2. ↑ 2.0 2.1 Lua error in package.lua at line 80: module 'strict' not found.
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  25. ↑ Lua error in package.lua at line 80: module 'strict' not found.


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