Sodelglitazar

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Sodelglitazar
Sodelglitazar skeletal.svg
Systematic (IUPAC) name
[4-[[[2-[2-Fluoro-4-(trifluoromethyl)phenyl]-4-methyl-1,3-thiazol-5-yl]methyl]sulfanyl]-2-methylphenoxy]-2-methylpropanoic acid[1]
Clinical data
Pregnancy
category
  • N/A
Legal status
  • Investigational
Identifiers
CAS Number 447406-78-2
ChemSpider 7981710
Chemical data
  • CC1=C(C=CC(=C1)SCC2=C(N=C(S2)C3=C(C=C(C=C3)C(F)(F)F)F)C)OC(C)(C)C(=O)O
  • InChI=1S/C23H21F4NO3S2/c1-12-9-15(6-8-18(12)31-22(3,4)21(29)30)32-11-19-13(2)28-20(33-19)16-7-5-14(10-17(16)24)23(25,26)27/h5-10H,11H2,1-4H3,(H,29,30)
  • Key:ZUGQWAYOWCBWGM-UHFFFAOYSA-N

Sodelglitazar, formerly known as GW 677954, is a thiazole PPARδ receptor agonist developed by GlaxoSmithKline.[2] While it is primarily active at the PPARδ receptor, it is considered a pan agonist with activity at PPARα and PPARγ receptors.[3]

Safety

Phase 2 studies were terminated prior to completion due to safety findings in rodent studies.[4]

See also

References

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  1. ↑ US Patent No. 7105551 Lua error in package.lua at line 80: module 'strict' not found.
  2. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  3. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  4. ↑ Lua error in package.lua at line 80: module 'strict' not found.
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