SLC10A2

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The SLC10A2 (solute carrier family 10 member 2) gene in humans encodes the bile acid:sodium symporter known as the Apical sodium-bile acid transporter (ASBT) or as the ileal bile acid transporter (IBAT).[1][2]

ASBT/IBAT is most highly expressed in the ileum where it is found on the brush border membrane of enterocytes. It is responsible for the initial uptake of bile acids, particularly conjugated bile acids, from the intestine as part of their enterohepatic circulation.[3]

The drug elobixibat is an inhibitor of ASBT/IBAT and is under development for the treatment of constipation and irritable bowel syndrome.[4]


See also

References

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Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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