SLC27A5

Solute carrier family 27 (fatty acid transporter), member 5
Identifiers
Symbols	SLC27A5 ; ACSB; ACSVL6; BACS; BAL; FACVL3; FATP-5; FATP5; VLACSR; VLCS-H2; VLCSH2
External IDs	OMIM: 603314 MGI: 1347100 HomoloGene: 7596 ChEMBL: 5196 GeneCards: SLC27A5 Gene
EC number	6.2.1.7
Gene ontology Molecular function • long-chain fatty acid-CoA ligase activity • ATP binding • fatty acid transporter activity • very long-chain fatty acid-CoA ligase activity • protein complex binding • cholate-CoA ligase activity Cellular component • endoplasmic reticulum • endoplasmic reticulum membrane • basal plasma membrane • integral component of endoplasmic reticulum membrane • protein complex Biological process • very long-chain fatty acid metabolic process • long-chain fatty acid metabolic process • triglyceride mobilization • bile acid biosynthetic process • bile acid metabolic process • bile acid and bile salt transport • plasma membrane long-chain fatty acid transport • small molecule metabolic process • ketone body biosynthetic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10998	26459
Ensembl	ENSG00000083807	ENSMUSG00000030382
UniProt	Q9Y2P5	Q4LDG0
RefSeq (mRNA)	NM_012254	NM_009512
RefSeq (protein)	NP_036386	NP_033538
Location (UCSC)	Chr 19: 58.48 – 58.51 Mb	Chr 7: 12.99 – 13 Mb
PubMed search	[1]	[2]

Bile acyl-CoA synthetase is an enzyme that in humans is encoded by the SLC27A5 gene.

The protein encoded by this gene is an isozyme of very long-chain acyl-CoA synthetase (VLCS). It is capable of activating very long-chain fatty-acids containing 24- and 26-carbons. It is expressed in liver and associated with endoplasmic reticulum but not with peroxisomes. Its primary role is in fatty acid elongation or complex lipid synthesis rather than in degradation. This gene has a mouse ortholog.

See also

• Solute carrier family