SCN7A

Sodium channel, voltage gated, type VII alpha subunit
Identifiers
Symbols	SCN7A ; NaG; Nav2.1; Nav2.2; SCN6A
External IDs	OMIM: 182392 MGI: 102965 HomoloGene: 55706 ChEMBL: 3585 GeneCards: SCN7A Gene
Gene ontology Molecular function • voltage-gated sodium channel activity Cellular component • voltage-gated sodium channel complex • plasma membrane • glial cell projection Biological process • sodium ion transport • muscle contraction • neuronal action potential • regulation of ion transmembrane transport • sodium ion transmembrane transport • sodium ion homeostasis • membrane depolarization during action potential Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE SCN7A 207864 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6332	20272
Ensembl	ENSG00000136546	ENSMUSG00000034810
UniProt	Q01118	B1AYL1
RefSeq (mRNA)	NM_002976	NM_009135
RefSeq (protein)	NP_002967	NP_033161
Location (UCSC)	Chr 2: 166.4 – 166.49 Mb	Chr 2: 66.67 – 66.78 Mb
PubMed search	[1]	[2]

Sodium channel protein type 7 subunit alpha is a protein that in humans is encoded by the SCN7A gene on the chromosome specifically located at 2q21-23 chromosome site. This is one of 10 Sodium channel types, and is expressed in the heart, the uterus and in glial cells. Its sequence identity is 48, and it is the only sodium channel known to be completely un-blockable by TTX (tetrodotoxin).

See also

• Sodium channel

Scn7a is the name of the gene that encodes to a membrane protein, in particular a Sodium Channel Na_x (also known as NaG, Na_v2.1, etc.) It belongs to a family of Sodium Channel known as Voltage-Gated, but is not activated by changes in the membrane's voltage, as happen usually in the members of this family (Na_v1.1 to Na_v1.9); it activates by changes in the extracellular concentration of sodium [~150 mM].

External links

• SCN7A protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.