Langerin
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). CD207, langerin (Cluster of Differentiation 207) is a protein which in humans is encoded by the CD207 gene.[1][2] Langerin is a type II transmembrane, C-type lectin receptor on Langerhans cells.[2][3]
Contents
Function
The protein encoded by this gene is expressed in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. Additionally it is known by the name C-type lectin domain family 4 member K (CD antigen CD207). It is also expressed in several other dendritic cell types including dermal CD103+ DCs and splenic CD8+ DCs. Langerin is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway.[1]
Clinical significance
Langerin on mucosal Langerhans cells of the human genital epithelium binds to HIV-1 and subsequently internalizes it into Birbeck granules to be degraded.[4][5]
See also
References
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External links
- CD207 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
