CD86

This article is about the molecule. For the compilation album, see CD86 (album).

CD86 molecule
250px PDB rendering based on 1i85.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1I85, 1NCN
Identifiers
Symbols	CD86 ; B7-2; B7.2; B70; CD28LG2; LAB72
External IDs	OMIM: 601020 MGI: 101773 HomoloGene: 10443 GeneCards: CD86 Gene
Gene ontology Molecular function • receptor activity • receptor binding • protein binding • coreceptor activity Cellular component • plasma membrane • external side of plasma membrane • cell surface • integral component of membrane • intracellular membrane-bounded organelle • extracellular exosome Biological process • response to yeast • toll-like receptor signaling pathway • adaptive immune response • T cell proliferation involved in immune response • negative regulation of T cell anergy • immune response • epidermal growth factor receptor signaling pathway • cell-cell signaling • aging • positive regulation of cell proliferation • fibroblast growth factor receptor signaling pathway • viral process • T cell costimulation • response to interferon-gamma • Fc-epsilon receptor signaling pathway • positive regulation of activated T cell proliferation • T cell activation • B cell activation • response to drug • myeloid dendritic cell differentiation • positive regulation of lymphotoxin A biosynthetic process • positive regulation of interleukin-2 biosynthetic process • innate immune response • positive regulation of interleukin-4 biosynthetic process • positive regulation of T-helper 2 cell differentiation • positive regulation of transcription, DNA-templated • neurotrophin TRK receptor signaling pathway • phosphatidylinositol-mediated signaling • defense response to virus • cellular response to lipopolysaccharide • cellular response to metal ion • cellular response to cytokine stimulus Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE CD86 205686 s at tn.png
File:PBB GE CD86 205685 at tn.png
File:PBB GE CD86 210895 s at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	942	12524
Ensembl	ENSG00000114013	ENSMUSG00000022901
UniProt	P42081	P42082
RefSeq (mRNA)	NM_001206924	NM_019388
RefSeq (protein)	NP_001193853	NP_062261
Location (UCSC)	Chr 3: 122.06 – 122.12 Mb	Chr 16: 36.6 – 36.67 Mb
PubMed search	[1]	[2]

Cluster of Differentiation 86 (also known as CD86 and B7-2) is a protein expressed on antigen-presenting cells that provides costimulatory signals necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD86 works in tandem with CD80 to prime T cells.

The CD86 gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. Alternative splicing results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined.

See also

• Cluster of differentiation
• CD80
• CD28
• CTLA-4
• List of human clusters of differentiation for a list of CD molecules

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.