Combretastatin A-1
From Infogalactic: the planetary knowledge core
| 200px | |
| Names | |
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| IUPAC name
3-Methoxy-6-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]benzene-1,2-diol
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| Other names
Combretastatin A1; OXi4500
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| Identifiers | |
109971-63-3  |
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| ChEMBL | ChEMBL520204  |
| ChemSpider | 4800178 |
| Jmol 3D model | Interactive image |
| PubChem | 6078282 |
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| Properties | |
| C18H20O6 | |
| Molar mass | 332.35 g·mol−1 |
| Vapor pressure | {{{value}}} |
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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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 verify (what is ?) |
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| Infobox references | |
Combretastatin A-1 is a combretastatin and a stilbenoid. It can be found in Combretum caffrum, the Eastern Cape South African Bushwillow tree.[1]
It is an antiangiogenic agent acting by destabilizing tubulin, which induces cell apoptosis of proliferating endothelial cells.[1]
Currently designated an orphan drug by the FDA, combretastatin A1 diphosphate (OXi4503 or CA1P) is in Phase I clinical trials for relapsed and refractory acute myeloid leukemia and myelodysplastic syndrome.[2]
References
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- ↑ 1.0 1.1 Lua error in package.lua at line 80: module 'strict' not found.
- ↑ http://clinicaltrials.gov/ct2/show/NCT01085656
