Aspartoacylase

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aspartoacylase (Canavan disease)
Identifiers
Symbol ASPA
Entrez 443
HUGO 756
OMIM 608034
RefSeq NM_000049
UniProt P45381
Other data
EC number 3.5.1.15
Locus Chr. 17 p13-ter
aspartoacylase (aminocyclase) 3
Identifiers
Symbol ACY3
Entrez 91703
HUGO 24104
RefSeq NM_080658
UniProt Q96HD9
Other data
Locus Chr. 11 q13

Aspartoacylase (EC 3.5.1.15, aminoacylase II, N-acetylaspartate amidohydrolase, acetyl-aspartic deaminase, acylase II) is a hydrolase enzyme with system name N-acyl-L-aspartate amidohydrolase.,[1][2] which breaks down N-acetylaspartate. A deficiency is associated with Canavan disease.This enzyme catalyses the following chemical reaction

N-acyl-L-aspartate + H2O \rightleftharpoons a carboxylate + L-aspartate

References

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External links


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