AC-262,356

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AC-262,356
File:AC-262,356.svg
Systematic (IUPAC) name
4-(3-endo-hydroxy-8-azabicyclo[3.2.1]oct-8-yl)naphthalene-1-carbonitrile
Identifiers
CAS Number 870888-46-3
871032-12-1 (exo form)
PubChem CID: 11673547
UNII U8VS41J5O6 YesY
Chemical data
Formula C18H18N2O
Molecular mass 278.348 g/mol
  • OC1CC(N2C3=CC=C(C4=C3C=CC=C4)C#N)CCC2C1
  • InChI=1S/C18H18N2O/c19-11-12-5-8-18(17-4-2-1-3-16(12)17)20-13-6-7-14(20)10-15(21)9-13/h1-5,8,13-15,21H,6-7,9-10H2
  • Key:ATKWLNSCJYLXPF-UHFFFAOYSA-N
  (verify)

AC-262,356 is a drug developed by Acadia Pharmaceuticals which acts as a selective androgen receptor modulator. Chemically it possesses endo-exo isomerism, with the endo form being the active form. It acts as a partial agonist for the androgen receptor with a Ki of 5nM, and no significant affinity for any other receptors tested. In animal studies it produced a maximal effect of around 66% of the anabolic action of testosterone, but only around 27% of its potency as an androgen.[1]

References

  1. ↑ Lua error in package.lua at line 80: module 'strict' not found.



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