UPF1
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Regulator of nonsense transcripts 1 is a protein that in humans is encoded by the UPF1 gene.[1][2]
Function
This gene encodes a protein that is part of a post-splicing multiprotein complex, the exon junction complex, involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene.[3]
Interactions
UPF1 has been shown to interact with:
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References
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<references />, or <references group="..." />Further reading
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This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it. |
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