Template:PBB/596

B-cell CLL/lymphoma 2
B-cell CLL/lymphoma 2
	PDB rendering based on 1GJH,1G5M.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1G5M, 1GJH, 1YSW, 2O21, 2O22, 2O2F, 2W3L, 2XA0, 4AQ3, 4IEH, 4LVT, 4LXD, 4MAN
Identifiers
Symbols	BCL2 ; Bcl-2; PPP1R50
External IDs	OMIM: 151430 MGI: 88138 HomoloGene: 527 ChEMBL: 4860 GeneCards: BCL2 Gene
Gene ontology
Molecular function	• protease binding; • protein binding; • transcription factor binding; • channel activity; • channel inhibitor activity; • ubiquitin protein ligase binding; • identical protein binding; • protein homodimerization activity; • sequence-specific DNA binding; • protein heterodimerization activity; • BH3 domain binding; • protein phosphatase 2A binding;
Cellular component	• nucleus; • cytoplasm; • mitochondrion; • mitochondrial outer membrane; • endoplasmic reticulum; • endoplasmic reticulum membrane; • cytosol; • membrane; • nuclear membrane; • myelin sheath; • pore complex;
Biological process	• protein polyubiquitination; • ossification; • ovarian follicle development; • metanephros development; • branching involved in ureteric bud morphogenesis; • behavioral fear response; • B cell homeostasis; • release of cytochrome c from mitochondria; • regulation of cell-matrix adhesion; • lymphoid progenitor cell differentiation; • B cell lineage commitment; • response to ischemia; • renal system process; • protein dephosphorylation; • melanin metabolic process; • regulation of nitrogen utilization; • apoptotic process; • humoral immune response; • cellular response to DNA damage stimulus; • actin filament organization; • axonogenesis; • female pregnancy; • cell aging; • male gonad development; • extrinsic apoptotic signaling pathway via death domain receptors; • intrinsic apoptotic signaling pathway in response to DNA damage; • intrinsic apoptotic signaling pathway in response to oxidative stress; • response to radiation; • response to toxic substance; • post-embryonic development; • response to iron ion; • response to UV-B; • response to gamma radiation; • regulation of gene expression; • negative regulation of autophagy; • negative regulation of calcium ion transport into cytosol; • regulation of glycoprotein biosynthetic process; • programmed cell death; • mesenchymal cell development; • positive regulation of neuron maturation; • positive regulation of smooth muscle cell migration; • cell growth; • peptidyl-serine phosphorylation; • peptidyl-threonine phosphorylation; • cochlear nucleus development; • gland morphogenesis; • regulation of transmembrane transporter activity; • negative regulation of ossification; • positive regulation of cell growth; • negative regulation of cell growth; • melanocyte differentiation; • negative regulation of cell migration; • positive regulation of B cell proliferation; • hair follicle morphogenesis; • axon regeneration; • regulation of protein stability; • endoplasmic reticulum calcium ion homeostasis; • glomerulus development; • negative regulation of cellular pH reduction; • negative regulation of myeloid cell apoptotic process; • T cell differentiation in thymus; • positive regulation of peptidyl-serine phosphorylation; • negative regulation of osteoblast proliferation; • response to cytokine; • response to nicotine; • organ growth; • nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway; • positive regulation of multicellular organism growth; • B cell proliferation; • cellular response to glucose starvation; • response to drug; • response to hydrogen peroxide; • T cell homeostasis; • negative regulation of apoptotic process; • positive regulation of catalytic activity; • CD8-positive, alpha-beta T cell lineage commitment; • regulation of protein homodimerization activity; • regulation of protein heterodimerization activity; • negative regulation of neuron apoptotic process; • ear development; • regulation of viral genome replication; • innate immune response; • positive regulation of melanocyte differentiation; • negative regulation of retinal cell programmed cell death; • regulation of mitochondrial membrane permeability; • focal adhesion assembly; • spleen development; • thymus development; • digestive tract morphogenesis; • oocyte development; • positive regulation of skeletal muscle fiber development; • pigment granule organization; • homeostasis of number of cells within a tissue; • B cell receptor signaling pathway; • response to glucocorticoid; • neuron apoptotic process; • defense response to virus; • regulation of mitochondrial membrane potential; • negative regulation of mitochondrial depolarization; • regulation of calcium ion transport; • transmembrane transport; • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; • cellular response to organic substance; • cellular response to hypoxia; • reactive oxygen species metabolic process; • extrinsic apoptotic signaling pathway in absence of ligand; • intrinsic apoptotic signaling pathway; • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; • negative regulation of G1/S transition of mitotic cell cycle; • negative regulation of reactive oxygen species metabolic process; • negative regulation of anoikis; • negative regulation of apoptotic signaling pathway; • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; • negative regulation of intrinsic apoptotic signaling pathway; • positive regulation of intrinsic apoptotic signaling pathway;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
Species	Human
Entrez	596
Ensembl	ENSG00000171791
UniProt	P10415
RefSeq (mRNA)	NM_000633
RefSeq (protein)	NP_000624
Location (UCSC)	Chr 18:; 63.12 – 63.32 Mb
PubMed search	[1]
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Template:PBB/596

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