SB-649,868
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SB-649,868 is a dual orexin receptor antagonist in development by GlaxoSmithKline.[1] The drug is currently in phase II development for insomnia.
A phase I study evaluated doses up to 80 mg, resulting in significant improvement in sleep latency without adverse effects.[2]
In randomized, double-blind, placebo-controlled crossover trials, the 10 and 30 mg doses increased sleep time and reduced sleep latency.[3] The subsequent study added a 60 mg dose and observed dose-dependent sleep promotion.[4]
See also
References
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Further reading
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α2-Adrenergic | |||||||||
5-HT2A |
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Orexin | |||||||||
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