Ro5-4864

Ro5-4864

Systematic (IUPAC) name
7-Chloro-5-(4-chlorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-one
Clinical data
Legal status	Not FDA approved
Identifiers
CAS Number	14439-61-3 Y
PubChem	CID: 1688
ChemSpider	1625
Chemical data
Formula	C16H12Cl2N2O
Molecular mass	319.185
SMILES Clc3ccc(cc3)C(=NCC1=O)c2cc(Cl)ccc2N1C
InChI InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 Key:PUMYFTJOWAJIKF-UHFFFAOYSA-N
(verify)

Ro5-4864 (4'-chlorodiazepam) is a drug which is a benzodiazepine derivative of diazepam. However unlike most benzodiazepine derivatives, Ro5-4864 lacks affinity for GABA_A receptors and lacks typical benzodiazepine effects, instead being sedative yet also convulsant and anxiogenic in effects. Ro5-4864 was found to be a potent ligand for the "peripheral benzodiazepine receptor", later renamed to mitochondrial translocator protein 18kDa (TSPO). Despite its convulsant effects, at lower doses Ro5-4864 has proved to be neuroprotective and has become widely used for research into the role of the TSPO protein in neurotoxicity. In vitro studies and rodent models also suggest the possibility of analgesic, antidepressant, cardioprotective, and anti-cancer effects.

See also

• Diclazepam (2'-chlorodiazepam)
• PK-11195