Reticular dysgenesis
From Infogalactic: the planetary knowledge core
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Reticular dysgenesis | |
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Classification and external resources | |
Specialty | Lua error in Module:Wikidata at line 446: attempt to index field 'wikibase' (a nil value). |
ICD-10 | D81.0 |
Patient UK | Reticular dysgenesis |
Reticular dysgenesis is a rare genetic disorder of the bone marrow resulting in complete absence of granulocytes and decreased number of abnormal lymphocytes. Production of red blood cells (erythrocytes) and megakaryocytes (platelet precursors) is not affected. There is also poor development of the secondary lymphoid organs.
Reticular dysgenesis is the most severe form of severe combined immunodeficiency (SCID). The cause of reticular dysgenesis is the inability of granulocyte precursors to form granules secondary to mitochondrial adenylate kinase 2 malfunction.
Further reading
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