PDGFRA

Platelet-derived growth factor receptor, alpha polypeptide
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1GQ5
Identifiers
Symbols	PDGFRA ; CD140A; PDGFR-2; PDGFR2; RHEPDGFRA
External IDs	OMIM: 173490 MGI: 97530 HomoloGene: 31361 ChEMBL: 2007 GeneCards: PDGFRA Gene
EC number	2.7.10.1
Gene ontology Molecular function • protein kinase activity • transmembrane receptor protein tyrosine kinase activity • platelet-derived growth factor alpha-receptor activity • vascular endothelial growth factor-activated receptor activity • platelet-derived growth factor receptor binding • protein binding • ATP binding • protein complex binding • vascular endothelial growth factor binding • protein homodimerization activity • phosphatidylinositol 3-kinase binding • platelet-derived growth factor binding Cellular component • nucleus • cytoplasm • cytosol • plasma membrane • integral component of plasma membrane • microvillus • external side of plasma membrane • membrane • intrinsic component of plasma membrane • protein complex Biological process • luteinization • in utero embryonic development • cell activation • hematopoietic progenitor cell differentiation • epidermal growth factor receptor signaling pathway • positive regulation of cytosolic calcium ion concentration • estrogen metabolic process • positive regulation of cell proliferation • fibroblast growth factor receptor signaling pathway • response to inorganic substance • negative regulation of platelet activation • positive regulation of phospholipase C activity • positive regulation of phosphatidylinositol 3-kinase signaling • viral process • peptidyl-tyrosine phosphorylation • signal transduction involved in regulation of gene expression • extracellular matrix organization • lung development • adrenal gland development • positive regulation of cell migration • male genitalia development • response to estradiol • Leydig cell differentiation • response to cytokine • cellular response to reactive oxygen species • platelet-derived growth factor receptor-alpha signaling pathway • positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway • Fc-epsilon receptor signaling pathway • wound healing • gliogenesis • odontogenesis of dentin-containing tooth • positive regulation of phosphatidylinositol 3-kinase activity • innate immune response • positive regulation of DNA replication • protein autophosphorylation • platelet-derived growth factor receptor signaling pathway • neurotrophin TRK receptor signaling pathway • phosphatidylinositol-mediated signaling • positive regulation of fibroblast proliferation • embryonic digestive tract morphogenesis • embryonic cranial skeleton morphogenesis • embryonic skeletal system morphogenesis • inner ear development • regulation of chemotaxis • cardiac myofibril assembly • response to hyperoxia • palate development • face morphogenesis • cell chemotaxis • retina vasculature development in camera-type eye • positive regulation of ERK1 and ERK2 cascade • platelet aggregation • cellular response to amino acid stimulus • metanephric glomerular capillary formation • regulation of actin cytoskeleton reorganization • regulation of mesenchymal stem cell differentiation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5156	18595
Ensembl	ENSG00000134853	ENSMUSG00000029231
UniProt	P16234	P26618
RefSeq (mRNA)	NM_006206	NM_001083316
RefSeq (protein)	NP_006197	NP_001076785
Location (UCSC)	Chr 4: 54.23 – 54.3 Mb	Chr 5: 75.15 – 75.2 Mb
PubMed search	[1]	[2]

Platelet-derived growth factor receptor, alpha polypeptide is a protein that in humans is encoded by the PDGFRA gene.

Function

This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes.

Interactions

PDGFRA has been shown to interact with:

• CRK,
• Caveolin 1,
• Cbl gene,
• PDGFC,
• PDGFR-β,
• PLCG1, and
• Sodium-hydrogen antiporter 3 regulator 1.

See also

• Platelet-derived growth factor receptor

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.