PDE4D
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). cAMP-specific 3',5'-cyclic phosphodiesterase 4D is an enzyme that in humans is encoded by the PDE4D gene.
Function
The PDE4D gene is complex and has at least 9 different isoforms that encode functional proteins. These proteins degrade the second messenger cAMP, which is a key signal transduction molecule in multiple cell types, including vascular cells (Dominiczak and McBride, 2003).[supplied by OMIM][1]
Interactions
PDE4D has been shown to interact with myomegalin[2] and GNB2L1.[3][4]
Clinical relevance
Mutations in this gene have been associated to cases of acrodysostosis.[5]
This is the subtype of PDE4 that appears to be involved in the emetic and antidepressant effects of PDE4 inhibitors.[6]
Furthermore, changes in expression of the isoform PDE4D7 have been proposed as prostate cancer biomarker. [7] [8]
References
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