PARD6A
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Partitioning defective 6 homolog alpha is a protein that in humans is encoded by the PARD6A gene.[1][2][3]
Function
This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[3]
Interactions
PARD6A has been shown to interact with:
References
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<references />, or <references group="..." />Further reading
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This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it. |
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