Oxaflozane

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Oxaflozane
Oxaflozane.svg
Systematic (IUPAC) name
4-Propan-2-yl-2-[3-(trifluoromethyl)phenyl]morpholine
Clinical data
Trade names Conflictan
Legal status
  • ℞ (Prescription only)
Routes of
administration
Oral
Identifiers
CAS Number 26629-86-8
26629-86-7 (HCl)
ATC code N06AX10 (WHO)
PubChem CID: 432824
ChemSpider 382782
UNII V4WLW77V5Q YesY
KEGG D07340
Synonyms CERM-1766
Chemical data
Formula C14H18F3NO
Molecular mass 273.29 g/mol
  • O1CCN(C(C)C)CC1c2cc(C(F)(F)F)ccc2

Oxaflozane (INN) (brand name Conflictan) is an antidepressant and anxiolytic drug that was introduced by Solvay in France in 1982 for the treatment of depression but has since been discontinued.[1][2][3][4] It is a prodrug of flumexadol (N-dealkyloxaflozane; 2-(3-trifluoromethylphenyl)morpholine; CERM-1841 or 1841-CERM), which is reported to act as an agonist of the serotonin 5-HT1A (pKi = 7.1) and 5-HT2C (pKi = 7.5) receptors and, to a much lesser extent, of the 5-HT2A (pKi = 6.0) receptor.[4][5] In addition to its serotonergic properties, oxaflozane may also produce anticholinergic side effects at high doses, namely in overdose.[6]

See also

References

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Further reading

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