MAPK10

Mitogen-activated protein kinase 10
Mitogen-activated protein kinase 10
	250px PDB rendering based on 1jnk.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1JNK, 1PMN, 1PMU, 1PMV, 2B1P, 2EXC, 2O0U, 2O2U, 2OK1, 2P33, 2R9S, 2WAJ, 2ZDT, 2ZDU, 3CGF, 3CGO, 3DA6, 3FI2, 3FI3, 3FV8, 3G90, 3G9L, 3G9N, 3KVX, 3OXI, 3OY1, 3PTG, 3RTP, 3TTI, 3TTJ, 3V6R, 3V6S, 4H36, 4H39, 4H3B, 4KKE, 4KKG, 4KKH, 4U79, 4W4V, 4W4W, 4W4X, 4W4Y, 4WHZ, 4Y46, 4Y5H, 4Z9L
Identifiers
Symbols	MAPK10 ; JNK3; JNK3A; PRKM10; SAPK1b; p493F12; p54bSAPK
External IDs	OMIM: 602897 MGI: 1346863 HomoloGene: 56439 ChEMBL: 2637 GeneCards: MAPK10 Gene
EC number	2.7.11.24
Gene ontology
Molecular function	• JUN kinase activity; • MAP kinase kinase activity; • protein binding; • ATP binding;
Cellular component	• nucleoplasm; • cytoplasm; • mitochondrion; • cytosol; • plasma membrane; • neuronal postsynaptic density;
Biological process	• activation of MAPK activity; • toll-like receptor signaling pathway; • MyD88-dependent toll-like receptor signaling pathway; • MyD88-independent toll-like receptor signaling pathway; • protein phosphorylation; • signal transduction; • JNK cascade; • JUN phosphorylation; • response to light stimulus; • toll-like receptor 2 signaling pathway; • toll-like receptor 3 signaling pathway; • toll-like receptor 4 signaling pathway; • toll-like receptor 5 signaling pathway; • toll-like receptor 9 signaling pathway; • toll-like receptor 10 signaling pathway; • TRIF-dependent toll-like receptor signaling pathway; • Fc-epsilon receptor signaling pathway; • toll-like receptor TLR1:TLR2 signaling pathway; • toll-like receptor TLR6:TLR2 signaling pathway; • regulation of circadian rhythm; • innate immune response; • rhythmic process; • regulation of sequence-specific DNA binding transcription factor activity; • stress-activated MAPK cascade;
	Sources: Amigo / QuickGO
RNA expression pattern
	File:PBB GE MAPK10 204813 at tn.png
	More reference expression data
Orthologs
Species	Human
Entrez	5602
Ensembl	ENSG00000109339
UniProt	P53779
RefSeq (mRNA)	NM_002753
RefSeq (protein)	NP_002744
Location (UCSC)	Chr 4:; 86.02 – 86.59 Mb
PubMed search	[1]
	v; t; e;

Mitogen-activated protein kinase 10 also known as c-Jun N-terminal kinase 3 (JNK3) is an enzyme that in humans is encoded by the MAPK10 gene.^[1]^[2]^[3]

Function

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kinase 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.^[3]