Lomefloxacin

Lomefloxacin

File:Lomefloxacin.svg
File:Lomefloxacin ball-and-stick.png
Systematic (IUPAC) name
(RS)-1-Ethyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxo-quinoline-3-carboxylic acid
Clinical data
Trade names	Maxaquin
AHFS/Drugs.com	Consumer Drug Information
MedlinePlus	a600002
Pharmacokinetic data
Protein binding	10%
Biological half-life	8 hours
Identifiers
CAS Number	98079-51-7 Y
ATC code	J01MA07 (WHO) S01AE04
PubChem	CID: 3948
DrugBank	DB00978 Y
ChemSpider	3811 Y
UNII	9VC7S3ZXXB Y
KEGG	D02318 Y
ChEBI	CHEBI:116278 Y
ChEMBL	CHEMBL561 Y
Chemical data
Formula	C17H19F2N3O3
Molecular mass	351.348 g/mol
SMILES Fc1c(c(F)c2c(c1)C(=O)C(\C(=O)O)=C/N2CC)N3CC(NCC3)C
InChI InChI=1S/C17H19F2N3O3/c1-3-21-8-11(17(24)25)16(23)10-6-12(18)15(13(19)14(10)21)22-5-4-20-9(2)7-22/h6,8-9,20H,3-5,7H2,1-2H3,(H,24,25) Y Key:ZEKZLJVOYLTDKK-UHFFFAOYSA-N Y
(verify)

Lomefloxacin hydrochloride (sold under the following brand names in English speaking countries Maxaquin, Okacyn, Uniquin) is a fluoroquinolone antibiotic used to treat bacterial infections including bronchitis and urinary tract infections. It is also used to prevent urinary tract infections prior to surgery. Lomefloxacin is associated with phototoxicity and central nervous system adverse effects.

October 2008 the FDA added the following black box warning to the product insert for Maxaquin: Lomefloxacin is unique in that it forms a magnesium chelate with itself. The chelate is formed between the 2-carbonyl group of two separate lomefloxacin molecules.

See also

• Quinolones