Leishmania braziliensis
| Leishmania braziliensis | |
|---|---|
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| Leishmania braziliensis |
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Leishmania brasiliensis is a Leishmania species.[1]
It is associated with leishmaniasis.
Signs and symptoms
Within a few months of infection, an ulcer forms. After healing there is an asymptomatic phase for three to twenty years. At this time, the parasite causes oral and nasal lesions causing severe damage to the mucus membranes.
Treatment
Pentostam, Liposomal and lipid complex preparations of Amphotericin B, or paromomycin can be given.
Sexual reproduction
Leishmania braziliensis, like other species of Leishmania rely on asexual reproduction in the intermediate mammalian host to greatly increase population density. Such reproduction is often witnessed in mononuclear phagocytes (dendritic cells, monocytes, neutrophils) of the mammalian host, with the macrophages being the target white blood cell of the parasite.[2] Recently, it has been hypothesized through two studies [3][4] that certain members of Leishmania genus (e.g. L. braziliensis) are capable of sexual reproduction in the gut of the sand-fly vector. More work is needed to establish a clear pattern of sexual reproduction in the genus.[5]
References
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- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Peters N, Egen J, Secundino N, Debrabant A, Kimblin N, Kamhawi S, Lawyer P, Fay M, Germain R, Sacks D. 2008. In Vivo Imaging Reveals an Essential Role for Neutrophils in Leishmaniasis Transmitted by Sand Flies. Science 321:970-974.
- ↑ Rougeron V, De Meeus T, Hide M, Waleckx E, Bermudez H, Arevalo J, Llanos-Cuentas A, Dujardin J, De Doncker S, Le Ray D, Ayala F, Banuls A. 2009. Extreme inbreeding in Leishmania braziliensis. Proceedings of the National Academy of Sciences 106:10224-10229.
- ↑ Volf PSadlova J. 2009. Sex in Leishmania. Science 324:1644-1644.
- ↑ Rougeron V, De Meeûs T, Kako Ouraga S, Hide M, Bañuls A. 2010. “Everything You Always Wanted to Know about Sex (but Were Afraid to Ask)” in Leishmania after Two Decades of Laboratory and Field Analyses. PLoS Pathog 6:e1001004.
