Interleukin 9

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Interleukin 9
Identifiers
Symbols IL9 ; HP40; IL-9; P40
External IDs OMIM146931 MGI96563 HomoloGene492 GeneCards: IL9 Gene
RNA expression pattern
File:PBB GE IL9 208193 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3578 16198
Ensembl ENSG00000145839 ENSMUSG00000021538
UniProt P15248 P15247
RefSeq (mRNA) NM_000590 NM_008373
RefSeq (protein) NP_000581 NP_032399
Location (UCSC) Chr 5:
135.89 – 135.9 Mb
Chr 13:
56.48 – 56.48 Mb
PubMed search [1] [2]

Interleukin 9, also known as IL-9, is a cytokine (cell signalling molecule) belonging to the group of interleukins.[1]

Function

The protein encoded by this gene is a cytokine produced by T-cells and specifically by CD4+ helper cells that acts as a regulator of a variety of hematopoietic cells. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin-9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. The gene encoding this cytokine has been identified as a candidate gene for asthma. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness.[1]

Interleukin-9 has also shown to inhibit melanoma growth in mice.[2]

References

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Further reading

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