Holoendemic

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A disease is holoendemic when essentially every individual in a population is infected.[1][2] As the disease is ubiquitous, the young are more likely to express pathogenic responses, whilst the older hosts will carry the disease asymptomatically, or with reduced damage, due to adaptive immunity.[2][3] Examples of this holoendemic pattern are seen with malaria in areas of sub-saharan Africa (where 75% of the deaths are in children under 5[4]) and trachoma in areas of Saudi Arabia.[5]

References

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