HLA-B58


HLA-B (alpha)-β2MG with bound peptide
major histocompatibility complex (human), class I, B58
Alleles	5801, 5802
Structure (See HLA-B)
Shared data
Locus	chr.6 6p21.31

HLA-B58 (B58) is an HLA-B serotype. B58 is a split antigen from the B17 broad antigen, the sister serotype B57.^[1] The serotype identifies the more common HLA-B*58 gene products.^[2] (For terminology help see: HLA-serotype tutorial) B*5801 is associated with allopurinol induced inflammatory necrotic skin disease.

Serotype

B58 and B17 serotype recognition of some more common HLA B*58 alleles^[3]
B*58	B58	B17	Sample
allele	%	%	size (N)
*5801	79	4	2096
*5802	72	3	837

Allele distribution

**HLA B*5801 frequencies**
		freq
ref.	Population	(%)
^[4]	Cameroon Pygmy Baka	15.0
^[4]	India Khandesh Pawra	15.0
^[4]	Cameroon Sawa	11.5
^[4]	Taiwan Hakka	10.9
^[4]	Kenya Nandi	10.0
^[4]	India West Bhils	9.0
^[4]	China South Han	8.9
^[4]	China Inner Mongolia	8.8
^[4]	India North Delhi	8.8
^[4]	Thailand Northeast	8.4
^[4]	Guinea Bissau	7.8
^[4]	Thailand	7.7
^[4]	India Mumbai Marathas	7.4
^[4]	India Andhra Pradesh Golla	7.2
^[4]	Kenya Luo	7.0
^[4]	Senegal Niokholo Mandenka	6.9
^[4]	India New Delhi	6.8
^[4]	Oman	6.8
^[4]	Russia Tuva (2)	6.7
^[4]	South Korea (3)	6.5
^[4]	Italy Sardinia (3)	6.4
^[4]	Burkina Faso Fulani	6.1
^[4]	Taiwan Siraya	5.9
^[4]	India North Hindus	5.8
^[4]	Burkina Faso Mossi	5.7
^[4]	Cameroon Yaounde	5.4
^[4]	Cameroon Bamileke	5.2
^[4]	Singapore Riau Malay	5.0
^[4]	Saudi Arabia Guraiat and Hail	4.6
^[4]	France Corsica	4.5
^[4]	Sudanese	4.5
^[4]	Zimbabwe Harare Shona	4.4
^[4]	Burkina Faso Rimaibe	4.3
^[4]	Iran Baloch	4.0
^[4]	South African Natal Zulu	4.0
^[4]	Tunisia	4.0
^[4]	Uganda Kampala	4.0
^[4]	Cameroon Beti	3.7
^[4]	Tunisia Ghannouch	3.7
^[4]	Taiwan Pazeh	3.6
^[4]	Tunisia Tunis	3.4
^[4]	Italy North (1)	3.3
^[4]	Israel Ashkenazi and Non Ashkenazi Jews	3.2
^[4]	India West Coast Parsis	3.0
^[4]	China North Han	2.9
^[4]	Ivory Coast Akan Adiopodoume	2.3
^[4]	Mali Bandiagara	2.2
^[4]	Mexico Zaptotec Oaxaca	2.2
^[4]	South Africa Natal Tamil	2.0
^[4]	China Yunnan Nu	1.9
^[4]	Bulgaria	1.8
^[4]	China Tibet Autonomous Region Tibetans	1.6
^[4]	France South East	1.6
^[4]	Israel Arab Druse	1.5
^[4]	Czech Republic	1.4
^[4]	Georgia Tibilisi Georgians	1.4
^[4]	Jordan Amman	1.4
^[4]	Morocco Nador Metalsa (berber)	1.4
^[4]	Croatia	1.3
^[4]	Romanian	1.3
^[4]	Spain Eastern Andalusia	1.2
^[4]	Australian Aborigine Cape York Peninsula	1.0
	*B5802**
^[4]	Cameroon Bamileke	14.3
^[4]	Kenya Luo	12.5
^[4]	Cameroon Yaounde	10.9
^[4]	Cameroon Pygmy Baka	10.0
^[4]	Cameroon Beti	9.8
^[4]	Kenya Nandi	8.5
^[4]	South African Natal Zulu	8.5
^[4]	Cameroon Sawa	7.7
^[4]	Zimbabwe Harare Shona	6.4
^[4]	Cape Verde Northwestern Islands	5.6
^[4]	Uganda Kampala	4.4
^[4]	Central Africa Republic Mbenzele Pygmy	4.0
^[4]	Zambia Lusaka	2.3
^[4]	Iran Baloch	1.0
^[4]	Tunisia	1.0

Disease

HLA-B*5801 is involved in allopurinol sensitive drug induced Stevens–Johnson syndrome.^[5]^[6] Allopurinol is a frequent cause of severe cutaneous adverse reactions, including drug-hypersensitivity syndrome, Stevens–Johnson syndrome, and toxic epidermal necrolysis (SJS/TEN).^[7] The association with allopurinol sensitivity in JSJ/TEN was extremely strong in Asia, and somewhat less associated in Europeans.^[8]

References

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↑ derived from IMGT/HLA
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[3] rived from IMGT/HLA

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HLA-B58

Contents

Serotype

Allele distribution

Disease

References

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