Dasabuvir

	File:Dasabuvir.svg
Systematic (IUPAC) name
	N-{6-[5-(2,4-Dioxo-3,4-dihydro-1(2H)-pyrimidinyl)-2-methoxy-3-(2-methyl-2-propanyl)phenyl]-2-naphthyl}methanesulfonamide
Clinical data
Trade names	Viekira Pak (with ombitasvir/paritaprevir/ritonavir tablets), Exviera
AHFS/Drugs.com	entry
Pregnancy; category	US: B (No risk in non-human studies); ;
Legal status	US: ℞-only;
Identifiers
CAS Number	1132935-63-7
ATC code	J05AX16 (WHO)
ChemSpider	29776744
ChEBI	CHEBI:85182
ChEMBL	CHEMBL3137312
Synonyms	ABT-333
Chemical data
Formula	C26H27N3O5S
Molecular mass	493.58 g/mol
	SMILES CC(C)(C)c1cc(cc(c1OC)c2ccc3cc(ccc3c2)NS(=O)(=O)C)n4ccc(=O)[nH]c4=O ;
	InChI InChI=1S/C26H27N3O5S/c1-26(2,3)22-15-20(29-11-10-23(30)27-25(29)31)14-21(24(22)34-4)18-7-6-17-13-19(28-35(5,32)33)9-8-16(17)12-18/h6-15,28H,1-5H3,(H,27,30,31) ; Key:NBRBXGKOEOGLOI-UHFFFAOYSA-N ;

Dasabuvir (trade name Exviera in Europe) is an antiviral drug for the treatment of hepatitis C virus (HCV) infection. In the United States, it is approved by the Food and Drug Administration for use in combination with ombitasvir, paritaprevir, and ritonavir in the product Viekira Pak.^[1]

Dasabuvir acts as a NS5B (an RNA-directed RNA polymerase) inhibitor.^[2]

References

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