Carnitine O-palmitoyltransferase

Choline/Carnitine o-acyltransferase
File:PDB 1ndi EBI.jpg Structure of carnitine acetyltransferase.
Identifiers
Symbol	Carn_acyltransf
Pfam	PF00755
Pfam clan	CL0149
InterPro	IPR000542
PROSITE	PDOC00402
SCOP	1ndi
SUPERFAMILY	1ndi
OPM superfamily	183
OPM protein	2h3u
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Carnitine O-palmitoyltransferase (also called carnitine palmitoyltransferase) is a mitochondrial transferase enzyme (EC 2.3.1.21) involved in the metabolism of palmitoylcarnitine into palmitoyl-CoA. A related transferase is carnitine acyltransferase.

Molecules

• Palmitoylcarnitine.PNG

  Palmitoylcarnitine

• Palmitoyl coenzyme A.svg

  Palmitoyl CoA

Pathway

Acyl-CoA from cytosol to the mitochondrial matrix

Human forms of CPT

There are four different forms of CPT in humans:

• CPT1A - associated with Carnitine palmitoyltransferase I deficiency
• CPT1B
• CPT1C
• CPT2 - associated with Carnitine palmitoyltransferase II deficiency

See also

• Fatty acid degradation#Transport into the mitochondrial matrix

External links

• PDOC00402 - Acyltransferases ChoActase / COT / CPT family in PROSITE
• Choline/Carnitine o-acyltransferase family in Pfam
• UMich Orientation of Proteins in Membranes protein/pdbid-2h4t
• Carnitine O-Palmitoyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)