ATG4A

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Autophagy related 4A, cysteine peptidase
250px
PDB rendering based on 2p82.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ATG4A ; APG4A; AUTL2
External IDs OMIM300663 MGI2147903 HomoloGene70873 GeneCards: ATG4A Gene
RNA expression pattern
File:PBB GE ATG4A 213115 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 115201 666468
Ensembl ENSG00000101844 ENSMUSG00000079418
UniProt Q8WYN0 Q8C9S8
RefSeq (mRNA) NM_052936 NM_174875
RefSeq (protein) NP_443168 NP_777364
Location (UCSC) Chr X:
108.09 – 108.15 Mb
Chr X:
140.96 – 141.16 Mb
PubMed search [1] [2]

Cysteine protease ATG4A is an enzyme that in humans is encoded by the ATG4A gene.[1][2][3]

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodelling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Transcript variants that encode distinct isoforms have been identified.[3]

References

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Further reading

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