ADAMTS8
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). A disintegrin and metalloproteinase with thrombospondin motifs 8 is an enzyme that in humans is encoded by the ADAMTS8 gene.[1][2]
Function
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs, and disrupts angiogenesis in vivo.[2]
Clinical significance
A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms.[2]
References
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External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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