Thorpe reaction
From Infogalactic: the planetary knowledge core
(Redirected from Ziegler condensation)
The Thorpe reaction is a chemical reaction described as a self-condensation of aliphatic nitriles catalyzed by base to form enamines.[1][2][3] The reaction was discovered by Jocelyn Field Thorpe.
Thorpe–Ziegler reaction
The Thorpe–Ziegler reaction (named after Jocelyn Field Thorpe and Karl Ziegler), or Ziegler method, is the intramolecular modification with a dinitrile as a reactant and a cyclic ketone as the final reaction product after acidic hydrolysis. The reaction is conceptually related to the Dieckmann condensation.
References
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External links
- Thorpe-Ziegler reaction: 4-Phosphorinanone, 1-phenyl- Organic Syntheses, Coll. Vol. 6, p.932 (1988); Vol. 53, p.98 (1973) Link
