UGT1A5

UDP glucuronosyltransferase 1 family, polypeptide A5
Identifiers
Symbols	UGT1A5 ; UDPGT; UDPGT 1-5; UGT1E
External IDs	OMIM: 606430 HomoloGene: 117984 GeneCards: UGT1A5 Gene
EC number	2.4.1.17
Gene ontology Molecular function • glucuronosyltransferase activity Cellular component • endoplasmic reticulum membrane • integral component of membrane • intracellular membrane-bounded organelle Biological process • flavonoid biosynthetic process • cellular response to hormone stimulus • flavonoid glucuronidation • xenobiotic glucuronidation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54579	n/a
Ensembl	ENSG00000240224	n/a
UniProt	P35504	n/a
RefSeq (mRNA)	NM_019078	n/a
RefSeq (protein)	NP_061951	n/a
Location (UCSC)	Chr 2: 233.71 – 233.77 Mb	n/a
PubMed search	[1]	n/a

UDP-glucuronosyltransferase 1-5 is an enzyme that in humans is encoded by the UGT1A5 gene.

Function

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.