Cephamycin

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Core structure of the cephamycins.

Cephamycins are a group of beta-lactam antibiotics. They are very similar to cephalosporins, and the cephamycins are sometimes classified as cephalosporins.

Like cephalosporins, cephamycins are based upon the cephem nucleus. Unlike most cephalosporins, cephamycins are a very efficient antibiotic against anaerobic microbes.

Cephamycins were originally produced by Streptomyces, but synthetic ones have been produced as well.

Cephamycins possess a methoxy group at the 7-alpha position.[1]

In addition, cephamycins have been shown to be stable against extended-spectrum beta-lactamase (ESBL) -producing organisms, although their use in clinical practice is lacking for this indication.

Examples

Cephamycins include:

References

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